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Synphase ®

Synphase is a combined pill used for contraception. It contains two different doses of hormones that are very effective at preventing pregnancy if you take it correctly.

With an EveAdam subscription plan, you can buy Synphase online and get it delivered to your door the next day.

Treatments from only £6.66 per month

Keeping contraception simple. Buy Synphase online.

Synphase is a combined hormonal contraceptive pill. It’s got two hormones in it that are prrretty difficult to say out loud: ethinylestradiol and norethisterone. Fortunately, that’s about as tricky as it gets as they do quite a simple job: they mimic how progesterone and oestrogen function in the body to protect you from becoming pregnant.

Prescriptions on a minimal fuss basis. With an EveAdam subscription, you can buy Synphase online and decide how regularly you’d like to receive your pill. It starts with a consultation with one of our licensed prescribers, who will check your medical background and talk you through the best pill options for you. Once you’ve chosen your pill, you can set your delivery schedule (every 3, 6, 9 or 12 months) and the quantity of pills you’d like to receive each time. Our clinician will put together a prescription for you and our pharmacy will dispense it.

You’ll get your first package delivered by secure courier as early as the next working day, and after that, we’ll work off your schedule.

How does Synphase work?

Synphase reduces your risk of pregnancy in three different ways.

The ovaries prepare the body for pregnancy by releasing an egg, so that the egg can be fertilised by sperm. The combined pill stops the ovaries from doing this, which helps to prevent fertilisation from happening.

The pill also makes the mucus in the cervix thicker, and this makes it harder for sperm to reach an egg (a tad grim sounding, we know, but if it stops you from getting pregnant, it’s a winner).

The lining of the uterus goes the opposite way with the combined pill – it’s made thinner, rather than thicker, which makes it harder for a fertilised egg to embed itself there and develop into a baby.

And that’s it. Synphase in a nutshell.

What type of pill is Synphase?

Synphase is what’s known as a ‘biphasic’ combined pill. It’s a bit of a flashy term, but all it means is that it’s a pill that has two different doses of hormones in it. So there are two types of pill in each strip that contain the same amount of oestrogen, but slightly different amounts of progesterone.

The doses that you take change part of the way through your cycle, to mimic the body’s natural hormonal changes during the menstrual cycle.

Although there are only two different doses of hormones in Synphase pills, you take these doses over three phases. It’s a 21 day pill, so you start by taking 7 blue pills of 500mg norethisterone, followed by 9 white pills of 1mg norethisterone, and then 5 blue pills of 500mg norethisterone.

Page reviewed by:
Dr Daniel Atkinson
Dr Daniel Atkinson
GP Clinical Lead
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Last updated 06/07/2021

What you need to know about Synphase

What is Synphase?

Synphase is a branded combined pill made by Pfizer. You take it for 21 days and then have a 7 day, pill-free break, before continuing to take it. Because it’s a biphasic pill containing two different doses of hormones, the pills are different colours to help you identify which dose of hormones to take and when during your cycle.

How effective is Synphase?

Can I buy Synphase online?

How to take Synphase pills

Each Synphase strip contains 21 pills, and each pill is marked with a row of bubbles indicating the days of the week. When you take your first pill, you should press the bubble for the day of the week you have started taking the pills on.

Take one pill each day, at the same time, in the correct order. You can take Synphase either with or without food.

If you take your first pill on the first day of your period, you’ll be protected from pregnancy immediately. If you don’t start taking Synphase on the first day of your period, you can start on days 2-5 of your cycle, but you will need to use additional contraception such as a condom for the first 7 days.

Once you’ve used all 21 pills, take a 7-day, pill-free break. It’s likely that you’ll experience bleeding during this time.

Having taken a 7-day break, start the next strip of pills, regardless of whether you’re still bleeding or not. You’ll always start a new strip on the same day of the week. Your protection from pregnancy remains the same during the 7-day pill-free window (provided that you always start a new strip on time).

What to do if you miss a Synphase pill

How will Synphase affect my periods?

What are the most common Synphase side effects?

Feeling sick, abdominal pain, tenderness in the breasts, headache, hypertension and changes in sex drive are all side effects that have been reported with Synphase.

These side effects tend to be mild and usually resolve by themselves, but if you find that they persist, or if they cause you greater discomfort, send our prescriber a message.

When should I see a doctor?

Can Synphase help treat acne?

Does Synphase cause depression?

Are biphasic pills better than monophasic or triphasic pills?

It all depends on you and your body. Women who experience side effects with monophasic pills (pills which contain the same amount of hormones in each strip) or triphasic pills (pills which have three different quantities of hormones in each strip) may find that they’re more suited to a biphasic pill. And vice versa. If you have a certain health condition, this can also determine which type of pill is more suitable for you than others.

Biphasic and triphasic pills mimic the natural menstrual cycle more closely than monophasic pills due to being made up of different doses of hormones, and some women may find that this is beneficial. But monophasic pills are very popular too, and many women find that they’re well suited to them.

Triphasic pills tend to cause less unexpected bleeding between periods than biphasic pills, so if you’re more prone to this, a triphasic pill may suit you more.

In short, then - it’s very much a case of how your body responds to hormones, and doses of those hormones, with your medical background factored into the equation. It’s taking these things into account that determines what type of pill is best for you.

Is Logynon a good alternative to Synphase?

If I want to switch from Synphase to another pill, what should I do?

Synphase safety information

Before you start using Synphase, you should always read the patient information leaflet that comes with your pill.

If anything is unclear, contact our clinician. They should be able to help. 

Synphase leaflet

Can Synphase interact with other medications?

Synphase can interact with other treatments, and some medications may impact on its effectiveness in the body. 

If you’re currently using, or have recently used, any other forms of medication, it’s very important that you inform our prescriber during your EveAdam consultation. 

Read more about the combined pill and interactions

Is Synphase suitable for everyone?


[1] NHS Choices (2019). Your contraception guide. [online] NHS. Available at:

[2] Cooper, D.B. and Mahdy, H. (2020). Oral Contraceptive Pills. [online] PubMed. Available at:

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